Abstract: Objective The aim of this study is to research the improvement effect of Jieduyihao （JDYH） on methamphetamine- induced learning and memory impairment in mice. Methods The experimental animals were randomly divided into 4 groups，the control group was given normal saline，the model group was given methamphetamine（10 mg/kg），the drug treatment groups were given different doses of JDYH（14. 12，56. 48 g/kg）. The spatial learning and memory were assessed with the Morris water maze，and the effects of JDYH on methamphetamine-induced spatial learning and memory impairment in mice were investigated. Results Compared with the control group，the escape latency in learning phase significantly prolonged in model group（P < 0. 05），which indicated the learning ability went down in the model group；In the model group，the times of the mice crossed platform in testing phase significantly went down（P < 0. 05 ），which indicated the impairment of memory in the model group. Compared with the model group，the escape latency in learning phase significantly shortened in low dose group（ P < 0. 05），and the times of the mice crossed platform in testing phase significantly went up（ P < 0. 05）；Compared with the model group，the escape latency had the trend of going down in high dose group，and the platform crossing times and time had the trend of going up，but the difference was not statistically significant. Conclusion JDYH can improve the learning and memory impairment induced by methamphetamine in mice.

Key words: Jieduyihao（JDYH）, methamphetamine（METH）, learning and memory, improvement effect