Journal of Jianghan University(Natural Science Edition) ›› 2019, Vol. 47 ›› Issue (1): 57-65.doi: 10.16389/j.cnki.cn42-1737/n.2019.01.010

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Effects of Jieduyihao on Methamphetamine-induced Behavioral Sensitization in Mice

LI Can1，TANG Lijun2，SI Yuanren3，XIAO Huaqiao3，RU Qin1，ZHOU Mei1，LI Chaoying*1   

  1. 1. Wuhan Institutes of Biomedical Sciences，Jianghan University，Wuhan 430056，Hubei，China；2. Hubei Provincial Key Laboratory for Applied Toxicology，Wuhan 430075，Hubei，China；3. Wuhan Wanji Psychiatric Hospital，Wuhan 430050，Hubei，China
  • Online:2019-02-28 Published:2019-02-25
  • Contact: LI Chaoying

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Abstract: Objective The aim of this study is to investigate the effects of Jieduyihao（JDYH）on the development，transfer and expression of methamphetamine（METH）-induced sensitization in mice. Methods The mice models of METH- induced hyperactivity with single dose administration and METH- induced behavioral sensitization with repeated intermittent administration were established. The effects of JDYH on the METH-induced hyperactivity and sensitization in mice were observed. Results Compared with the control group，the locomotor activity and hyperactivity of mice have no change after being treated with low- dose（14. 12 g/kg） and high- dose（56. 48 g/kg） of JDYH. Compared with the model group，the development，transfer and expression of METH- induced sensitization in JDYH treated mice were significantly suppressed. Conclusion JDYH can extraordinary inhibit the development，transfer and expression of METH-induced sensitization in mice，it suggests that JDYH may be a promising candidate for the management of METH addictions.

Key words: methamphetamine（METH）, behavioral sensitization, Jieduyihao（JDYH）

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