Journal of Jianghan University(Natural Science Edition) ›› 2016, Vol. 44 ›› Issue (5): 422-426.doi: 10.16389/j.cnki.cn42-1737/n.2016.05.007

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Effect of Levo-Tetrahydropalmatine on Methamphetamine-Seeking Behavior Induced by Conditioned Cues in Rats

GONG Xiaokang1，YUE Kai1，MA Baomiao1，GAN Yongping2，JIN Guozhang1，3，LI Chaoying*1   

  1. 1. Wuhan Institutes of Biomedical Sciences，Jianghan University，Wuhan 430056，Hubei，China；2. Drug Prevention and Education Center，Hubei Public Security Bureau，Wuhan 430070，Hubei，China；3. Shanghai Institute of Materia Medica，Chinese Academy of Sciences，Shanghai 201203，China
  • Online:2016-10-28 Published:2016-11-04
  • Contact: LI Chaoying

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Abstract: Objective To investigate effects of levo-tetrahydropalmatine（l-THP）on the reinstatement of methamphetamine induced by conditioned cues in rats. Methods Rats were trained to self-administer methamphetamine under fixed ratio 1（FR1）scheduler until stable responding was established. Following withdrawal（14d），rats randomly divided into four groups. Each group respectively received one doses of l-THP treatment（0，1. 25，2. 50，5. 00 mg/kg，i. p.）and cues-induced methamphetamine seeking behavior was recorded. Results As compared with 0 mg/kg l-THP pretreatment group， l-THP（1. 25，2. 50，5. 00 mg/kg，i. p.）pretreatment group significantly decreased the number of active nose poke（ P < 0. 01）. In contrast，inactive nose poke had no significantly difference（all P > 0. 05）.Conclusion l-THP（1. 25，2. 50，5. 00 mg/kg，i. p.）can inhibit the reinstatement of methamphetamine induced by cues in rats.

Key words: levo-tetrahydropalmatine, methamphetamine, conditioned cues, reinstatement, rats

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