Journal of Jianghan University(Natural Science Edition) ›› 2017, Vol. 45 ›› Issue (4): 307-316.doi: 10.16389/j.cnki.cn42-1737/n.2017.04.003

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Research and Application of Biocompatibility Carrier for Sustained-Release of Bone Morphogenetic Protein-2

ZHENG Zhiqiang1a，1b，LEI Yang1a，1b，YOU Qingliang1b，TIAN Yu1b，ZHANG Zhengtao1a，HE Rongxiang1a，CHEN Yong1a，2，ZHANG Weiying*1a，CAO Yiping1a，1b   

  1. 1. a. Institute for Interdisciplinary Research；b. Key Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of Education，Jianghan University，School of Chemistry and Environmental Engineering，Wuhan 430056，Hubei，China；2. Département de Chimie，Ecole Normale Supérieure，24 Rue Lhomond，F-75231 Paris Cedex 05，France
  • Online:2017-08-28 Published:2017-09-01
  • Contact: ZHANG Weiying

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Abstract: Bone morphogenetic protein-2（BMP-2）is a transforming factor and is a multifunctional growth factor，which plays an important role in cell proliferation，differentiation，migration and reconstruction. BMP- 2 is an important stimulative factor of bone repairing in the clinic application. However，BMP-2 is unstable in vivo，and one common problem is the burst release at very early stages without the protection of a carrier. The growth and differentiation of bone are dynamic processes. Therefore，a controllable release carrier is needed to prevent the burst release. In this paper，we described four controllable release carriers of BMP-2，including hydrogel and microcapsule，layer-bylayer self-assembly（LbL），surface micro processing of titanium and electrospinning.

Key words: bone morphogenetic protein-2（BMP-2）, controllable release, bone repairing

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