Abstract: The supramolecular hydrogel，made of oligopeptide in a self-assembled way，is a kind of three-dimensional nanostructures formed through non-covalent bond force in aqueous solution. It owns so many advantages，such as easy to design and modify chemical properties， good biological modification， low immunotoxicity， easy to degrade， rapid response，and other biological characteristics. The L-amino acid oligopeptide hydrogelator，specially designed and synthesized， has been widely used in the field of biomedicine，especially in the research of cancer treatment. Due to better biological stability，D-amino acids are preferred in biomedicine than L-amino acids. Supramolecular hydrogel，selfassembled from oligopeptides synthesized from D-amino acids，will be more widely studied in cancer treatment. In this paper，supramolecular hydrogel prepared by D-amino acid oligopeptides and their derivatives as hydrogel are introduced，and their applications in the treatment of cancer are summarized. Also，the disadvantages and challenges of supramolecular hydrogel prepared by D-amino acid oligopeptides in cancer therapy are discussed.

Key words: D-amino acid, supermolecular hydrogel, cancer therapy