Abstract: Objective To compare changes of platelet parameters in patients with acute ischemic cerebral apoplexy who have been treated with ticagrelor and clopidogrel. Methods The authors have chosen 65 cases of patients with acute ischemic cerebral apoplexy within 24 hours in Wuhan No. 1 Hospital from January 2015 to December 2016，who were randomly divided into ticagrelor group and clopidogrel group. Changes of platelet parameters were then evaluated before treatment，7 days and 3 months after treatment，including PLT（platelet count ），PCT（platelet hematocrit），PDW（platelet distribution width） and MPV（mean platelet volume）. Results PDW increased both in clopidogrel group and ticagrelor group 7 days and 90 days after treatment，the growths were 5% and 2%，respectively. The difference was statistically significant（ P < 0. 05）. Rates of bleeding events or other adverse reactions，PLT，PDW，PCT and MPV of the two groups showed no significant difference（ P > 0. 05）. Conclusion Compared with clopidogrel，ticagrelor increases platelet width with low amplitude，thereby has better effect on anti- activation and anti- aggregation of platelet，and do not increase bleeding and otheradverse events，it is expected to become the first- line drugs instead of clopidogrel on platelet aggregation.

Key words: cerebral apoplexy, clopidogrel, ticagrelor, platelet parameter