Abstract: Objective To observe the prevention effect on laryngeal edema after tracheal extubation with budesonide nebulization inhalation. Methods The research chose patients taken tracheal intubation and tracheal extubation from Jan. 2015 to Dec. 2016 in emergency care unit of the Central Hospital of Wuhan，and randomly divided the patients into experimental group and control group. The experimental group was treated with budesonide nebulization inhalation after tracheal extubation while the control group was treated with normal saline nebulization inhalation，the indexes of dyspnea incidence，blood oxygen saturation（SpO₂），arterial partial pressure of oxygen（PaO₂），arterial partial pressure of carbon dioxide（PaCO₂）and respiratory rate（RR）were observed. Results 30 min after nebulization inhalation，compared with the control group，the indexes of experimental group of PaO₂ and SpO₂ increased，the differences were statistic significant（ P < 0. 05），the indexes of PaCO₂ and RR had no obvious change. 60 min after nebulization inhalation， in the experimental group， the PaCO₂ significantly decreased， the SpO₂ significantly increased， the RR significantly fell down， thedifferences were statistic significant（ P < 0. 05）；the PaO₂ had no obvious change. The incidence of laryngeal edema in experimental group was obvious lower than that in control group（ P < 0. 05）.Conclusion Budesonide nebulization inhalation after tracheal extubation can effectively improve oxygenation and reduce laryngeal edema，it is worthy to popularize.

Key words: laryngeal edema, budesonide, nebulization inhalation, methylprednisolone