Abstract: Objective To investigate relationships and diagnosis value of urine β2- microglobulin（β2-MG），plasma high sensitive C-reactive protein（hsCRP）and interleukin-6（IL-6）such inflammatory factors in early renal damage of type-2 diabetic patients with hypertension. Methods Urine and plasma samples were collected from 125 type-2 diabetic patients with hypertension and 75 healthy volunteers，and urine β2-MG，hsCRP，IL-6，BUN，SCr，HbAlc of the two groups were tested and compared. Results Urine β2-MG，plasma hsCRP and IL-6 levels of diabetic patients group were higher than those of the healthy group when BUN and SCr were normal range，the difference was statistically significant（ P < 0.05）.There was a positive correlation between urine β2- MG and plasma hsCRP，IL- 6 of diabetic patients. The higher the HbAlc level， the higher the urine β2 - MG， plasma hsCRP and IL- 6. Conclusion A considerable proportion of diabetic patients with hypertension have low renal function while their BUN，SCr are still normal，Urine β2-MG and plasma hsCRP，IL-6 have a good correlationwith early renal damage of diabetic patients with hypertension. It is suggested that combined detection can benefit the diagnosis of early renal damage in such patients，and is in favor of early intervention.

Key words: type-2 diabetes mellitus, hypertension, β2-microglobulin, inflammatory factors, early renal damage