Abstract: Objective：To discuss the comprehensive application of 64-slice spiral CT scan techniques on the diagnosis value of nodular goiter and its differential diagnostic value.Methods：41 cases of nodular goiter，thyroid tumors and other nodular thyroid diseases，which had been verified by pathology，were selected to conduct 64-slice spiral CT scan and dynamic contrast-enhanced scan plus follow-up reconstruction. With observing the size，shape，density，edge，enhancing characteristics of the lesion as well as its infringement and metastasis，imaging characteristics of the lesion were concluded. Results：The imaging manifestations of nodular goiter，thyroid tumors and other nodular thyroid diseases overlap only in small portion on CT，but mostly they are different. Conclusion：The comprehensive application of 64-slice spiral CT scan techniques can considerably di? agnose the representations and characteristics of nodular goiter and similar diseases，which is significant to the diagnosis and differential diagnosis of nodular goiter.