Abstract: Objective To investigate the clinicopathological features and differential diagnosis of solitary fibrous tumors of the central nervous system. Methods Routine HE and immunohistochemical staining were performed in 5 cases of solitary fibrous tumors of the central nervous system，and follow-up was conducted. At the same time，their clinicopathological features were analyzed in conjunction with the review of relevant literature. Results The morphologic features of the lesions were diverse. The main lesions were densely proliferated spindle tumor cells arranged into sheet striations and hemangiopericytoma-like structures. In addition，the area of loose cells is also seen. The tumor cells are scattered in a star-awn shape，accompanied by collagen fiber hyaline changes. Vimentin，CD34，CD99，STAT6 and Bcl-2 were positively expressed in spindle cells. With the increase of tumor grade，the Ki-67 value-added index increased（5%-20%）. p53 was positively expressed in mid-and high-level lesions. In the whole group，1 patient relapsed and 1 lost to follow-up. Conclusion Solitary fibrous tumors originating in the central nervous system are rare，which are intermediate neoplasms with a tendency to recur. Histomorphology is an important diagnostic basis，and immunohistochemical examination can assist the diagnosis and differential diagnosis.

Key words: central nervous system, solitary fibrous tumor, differential diagnosis