Abstract: To screen high yield and good quality Prunella L. varieties，which will be suitable for cultivation at Qichun areas，the yield and quality of four Prunella L. varieties（Anhui Bozhou，AHX；Hubei Qichun，HQX；Jiangxi Zhangshu，JZX；Henan Queshan，HNX）were evaluated using randomized block design，taking the same plot，the same sowing planted period，with two ways which were direct sowing culture and transplanting cultivation. The results showed that JZX and HNX， the comprehensive performance， whether quality content （rosmarinic acid content were 0.42% and 0. 40%，respectively）or yield（the average yield of dry grain per mu （667 m²）were 168. 0 kg and 159. 3 kg，respectively）were better. Research of two culture methods for AHX and HQX showed that direct sowing culture was higher than transplanting cultivation. Suggests that JZX and HNX should be developed in a large area for introduction demonstration and promotion in Qichun areas，and HQX should be moderately developed，and should focus on direct sowing culture.

Key words: Prunella L., Chinese medicinal plant, cultivation method, yield, quality