Abstract: Objective To investigate the effect of deep hyperthermia combined with Endostar and cisplatin intrapleural infusion chemotherapy on immune function and tumor markers and short- term curative effect in patients with malignant pleural effusion.Methods 70 patients with malignant pleural effusion treated in the oncology department of the Third People′s Hospital of Hubei Province from 2020 to 2023 were selected and randomly divided into an observation group and a control group，with 35 patients in each group. The observation group received deep hyperthermia combined with Endostatin （recombinant human Endostatin） and cisplatin intrapleural thermal perfusion， while the control group only received pure Endostatin and cisplatin intrapleural thermal perfusion. The immune-related indexes（CD4+，CD8+，CD4+/CD8+），tumor marker（CEA，CA19-9，CA125），shortterm curative effect，the occurrence rate of toxic and side effects during treatment，and the improvement rate of life quality after treatment were observed.Results The total effective rate of the observation group （82. 86%） was significantly higher than that of the control group （48. 57%）（P < 0. 05）. The observation group was significantly larger than the control group in terms of CD4+ and CD4+/CD8+ （P < 0. 05）. In addition，the serum levels of CEA，CA125，and CA19-9 in the two groups were decreased，but the decrease of the observation group was significantly greater than that of the control group（P < 0. 05）. The improvement rate of life quality in the observation group（77. 13%）was significantly better than that in the control group（42. 85%）（P < 0. 05），and there was no significant difference in the incidence of adverse reactions （ADR） between the two groups （P > 0. 05）.Conclusion Deep hyperthermia combined with Endostar and cisplatin thoracic hyperthermic perfusion chemotherapy can improve the immune function of patients，regulate the level of tumor markers，have a good short- term curative effect on malignant pleural effusion，and effectively improve the life quality of patients.

Key words: malignant pleural effusion, hyperthermic perfusion, deep hyperthermia, tumor markers, tumor immunity