Abstract: Objective To investigate the value of calcitoninogen （PCT） to predict anastomotic leakage （AL） after colorectal surgery using meta-analysis.Methods We searched literature about predicting the risk of anastomotic leakage after colorectal surgery with calcitoninogen in eight major databases，including PubMed，CNKI，and CBM，for the keywords ″ anastomotic leakage″ ，″ anastomotic fistula″ ，and ″ calcitoninogen″. The studies that met the inclusion and exclusion criteria were evaluated by QUADAS-2 risk of bias and visualized using Review Manager 5.3 software to determine the final literature for inclusion in the Meta-analysis，and Stata 14.0 and Meta DiSc 1.4 software were used to analyze the diagnostic value of calcitoninogen on anastomotic leakage after colorectal surgery.Results A total of 455 papers were searched with the corresponding keywords，and 10 papers were finally categorized. Meta-analysis suggested that the combined sensitivity of PCT on postoperative day 5 for predicting AL after colorectal surgery in the included literature was 0. 85（95%CI（0. 76，0. 91）），and the combined specificity was 0. 85（95%CI（0. 83， 0. 87））. The combined AUC = 0. 914 9 and Q-index = 0. 847 5； the combined diagnostic ratio DOR was 32. 89（95%CI（17. 44， 62. 03））.Conclusion PCT in the laboratory on the fifth postoperative day to predict AL after colorectal surgery has important clinical value.

Key words: calcitoninogen, anastomotic leakage, colorectal surgery, Meta-analysis