Abstract: Objective To investigate the knowledge，attitude，and practice（KAP）related to COVID-19 and the satisfaction with the prevention and control of COVID-19 in urban and Rural Residents in Zunyi City，and provide a reference for the health education and prevention and control of COVID-19. Methods Through online and offline questionnaires， the stratified multistage sampling method was used to investigate the KAP and satisfaction of urban and rural residents in Zunyi City for the prevention and control of the COVID-19 epidemic，and to analyze the differences and influencing factors of KAP among residents with different characteristics. Results A total of 603 valid questionnaires were collected. The total awareness rate of COVID-19 among residents was 79. 43%. There was a significant difference in the awareness of COVID-19 among different ages，educational levels，and occupations （P < 0. 05）. The proportion of residents with a positive attitude towards COVID-19 was 87. 23%，while there was no significant difference in the attitude of residents with different characteristics（P > 0. 05）. Moreover，93. 37% of them had good behavior in preventing the COVID-19 virus，while the differences among residents with different education and occupation were statistically significant（P < 0. 05）. The result of multivariate analysis showed that residents with low education levels had lower cognition of COVID-19 than those with high education levels OR = 0. 647（95%CI 0. 548，0. 764）. The residents with high cognition took better protective behavior than those with low cognition OR = 0. 531（95%CI 0. 328，0. 860）. Conclusion Urban and rural residents have a high degree of satisfaction，a good KAP，and a high level of enthusiasm for COVID-19 prevention and control. However，it is necessary to strengthen the publicity and education of COVID-19 in vulnerable groups （such as low education levels and older/younger） to better promote the precise prevention and control of COVID-19.

Key words: COVID-19, knowledge，attitude and practice（KAP）, satisfaction, urban and rural residents