Abstract: Objective To explore the clinical efficacy of biological patch fixation with different materials in laparoscopic transperitoneal hernia patch repair（TAPP）. Methods In a matched case-control study，21 patients who underwent TAPP with biological screw fixation patch in the first Department of General Surgery of the First Affiliated Hospital of Dali University from July 11，2016 to July 15，2021 were selected as the biological screw fixation group. The matching conditions were gender，surgical side，age，the same operator，hernia type，and fixation method. 21 patients who underwent TAPP with medical biological glue fixed patch during the same period were selected as the control group（biological glue fixed patch group），and the clinical effects of the two groups were compared. Results The two materials were compared in terms of operative time，intraoperative blood loss，postoperative hospital stay，time of catheter removal，pain rate on the first postoperative day，seroma incidence，urinary retention incidence，postoperative complication rate，the postoperative incidence of postoperative foreign body sensation ， postoperative recurrence rate ， postoperative chronic pain incidence，and overall satisfaction after the operation，and there was no significant difference（P > 0. 05）. But there was a significant difference in total hospitalization expenses，and the mean difference in hospitalization expenses between the two groups was 888. 39 yuan（P < 0. 05）. Conclusion The biological screw fixation patch or biological glue fixation patch in TAPP can safely and effectively treat inguinal hernia，but biological glue fixation is more economical and less burdensome on patients，which can be recommended for clinical promotion.

Key words: inguinal hernia, hernia repair, fixed patch, case-control study