Abstract: Objective To observe the clinical efficacy of the traditional Chinese medicine compound Mintuole combined with fire acupuncture in the treatment of chronic eczema，and further explore the possible action mechanism. Methods A total of 286 clinical cases were selected and randomly divided into the control group and the observation group according to the double-blind principle. The control group was given conventional anti-allergic treatment， and the observation group was given Mintuole orally combined with fire needling external therapy. Efficacy was assessed after 4 weeks of treatment. Further，based on network pharmacology and bioinformatics' theory，the differential genes of the two groups of patients were analyzed before and after treatment. INF- γ，IL-4，EOS，and IgE were selected as the efficacy observation indexes to explore the mechanism of drug action. Results In the clinical observation，the effective rate of the observation group was 89. 7% and the effective rate of the control group was 77. 2%. The therapeutic effect of the observation group was better than that of the control group（P < 0. 05）. Eczema area and severity index（EASI）and dermatology life quality index（DLQI）scores were evaluated. The scores in the observation group decreased significantly compared with those in the control group（P < 0. 05）. In the experimental study，compared with the control group，IL-4，EOS，and IgE in the observation group were significantly decreased， and INF- γ was significantly increased after treatment（P < 0. 05）. Conclusion Mintuole combined with fire acupuncture therapy is effective in treating chronic eczema and can significantly regulate the body's immune mechanism.

Key words: traditional Chinese medicine prescription, fire acupuncture, chronic eczema, curative effect observation, action mechanism