Journal of Jianghan University (Natural Science Edition) ›› 2022, Vol. 50 ›› Issue (6): 59-68.doi: 10.16389/j.cnki.cn42-1737/n.2022.06.007

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Analysis of Dosing Pattern of Chinese Medicine Fumigation for Vertebral Artery Type Cervical Spondylosis Based on Data Mining Technology

ZHANG Lei,PAN Tianyu,REN Jiaojiao,REN Tingting,YOU Jun,ZHU Shuxiu*   

  1. School of Medicine,Jianghan University,Wuhan 430056,Hubei,China
  • Published:2022-12-19
  • Contact: ZHU Shuxiu

Abstract: Objective Excavating the grouping and medication rules of Chinese medicine fumigation for treating vertebral artery type cervical spondylosis. Methods Using ″ cervical spondylosis″ ,″ Xiang paralysis″ ,and ″ Chinese medicine fumigation″ as keywords,we searched the relevant literature from CNKI,WanFang,and VIP databases until February 28,2022. The frequency analysis,association rule analysis,factor analysis,and cluster analysis were performed on the Chinese medicine fumigation prescriptions with the inclusion criteria using Excel 2016,SPSS Modeler 18.0,and SPSS Statistics 26.0 statistical. Results 53 journal articles met the inclusion criteria,involving 64 prescriptions,106 herbs,and 10 toxic Chinese medicines. The top 5 high-frequency herbal medicines were Honghua,Chuanxiong,Weilingxian,Danggui,and Qianghuo. The classification of Chinese herbal medicines was mainly based on activating blood circulation and eliminating wind dampness,the four qi were mainly warm,the five tastes were mainly pungent,and the generalized meridian was mainly liver meridian. Toxic herbal medicines were more frequently used for Zhichuanwu,Aiye,Zhicaowu,etc. The classification of herbal medicines was mainly based on dispelling wind-dampness and invigorating blood stasis,the four qi were mainly hot,the five tastes were mainly bitter and pungent,and the generalized meridians were mainly liver meridians and spleen meridians. The formulae were analyzed by association rules to obtain 14 high-frequency drug combinations,and factor analysis could extract 6 common factors,which were grouped into 4 major categories by systematic clustering analysis. Conclusion Treating vertebral artery type cervical spondylosis by Chinese medicine fumigation is based on dispelling wind-dampness,activating blood circulation,and resolving blood stasis. Analyzing the formulae pattern of Chinese medicine fumigation for vertebral artery type cervical spondylosis by data mining technology can provide some reference for prescribing vertebral artery type cervical spondylosis and developing new drugs.

Key words: Chinese medicine fumigation, vertebral artery type cervical spondylosis, data mining, dosing pattern

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