Abstract: Objective To study the effect of Wuqinxi on proprioception sensation and balance function of female patients with knee osteoarthritis. Methods In Anhui Province，at the First People′s Hospital of Bozhou from January 2016 to January 2017，118 cases of female patients with knee osteoarthritis were chosen as the study object，according to the exercise therapy of Wuqinxi，the patients were divided into experimental group and control group，59 patients in the control group were not given Wuqinxi exercise therapy，59 patients in the experimental group were given the treatment of Wuqinxi exercise and the clinical effects of two groups were compared. Results After 1 months of treatment，in the experimental group，57 patients′ conditions were improved，50 patients′ conditions in the control group were improved. With the passing of time，in the experimental group，the arthritis index（WOMAC）scores were significantly better than those in the control′ group. For the patients in the experimental group after 3 months of treatment，the total number of attitude stability index（OSI）score，knee joint stability limit time（TCT）score and dynamic fall risk（DFI）score were significantly better than those in the control group，data of two groups of patients had difference with statistical significance（ P < 0. 05）.Conclusion For female patients with knee osteoarthritis，the Wuqinxi exercise therapy can effectively reduce the knee joint pain，swelling and other symptoms，improve knee balance function.

Key words: Wuqinxi, female knee osteoarthritis, proprioception sensation, balance function, total number of attitude stability index（OSI）, arthritis index（WOMAC）, dynamic fall risk（DFI）