Abstract: Lysine acetylation of histone plays an important role in regulation of gene expression in plant cells，meanwhile it affects the enzyme activity of glycolysis，tricarboxylic acid cycle and photosynthetic pathway. Therefore，it is of great significance to identify histone acetyltransferase（HAT）and histone deacetylase（HDAC）of metabolism regulating enzymes. On the contrary，metabolites such as acetyl-CoA and NAD+ are involved in processes of protein acetylation and deacetylation，their intracellular levels may influence on activity of HAT and HDAC. This paper illustrates the role of HAT，HDAC and their research progress from protein lysine acetylation process，classification and cell distribution，and metabolic enzyme activity.

Key words: HAT, HDAC, acetyl-CoA, gene expression, metabolic enzymes activity