Table of Content

28 October 2018, Volume 46 Issue 5

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Antipad Design and Its Influence on High Frequency Characteristics of Differential Vias

LUO Huirong，HE Wenhao

2018, 46(5):  389-394.  doi:10.16389/j.cnki.cn42-1737/n.2018.05.001

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With the improvement of the differential signal rate，the influence of differential vias on the signal integrity of the high-speed differential signal is more and more noticeable. Aiming at the design requirements of low reflectance，high-transmission and stable impedance of differential vias in high-speed PCB，the antipad prediction was calculated by equivalent vias model. According to the estimated value，different shapes of differential vias antipad were simulated and analyzed. Differential vias in a 16-layer PCB were modeled in 3D and simulated with HFSS，and the model was simulated and analyzed in eye diagram with software of Designer. The results showed that the larger the area of antipad in a certain frequency range，the better the high frequency characteristics of the differential vias.

Output Characteristics Analysis of Photovoltaic Array under Shadow Conditions

YANG Hao

2018, 46(5):  395-403.  doi:10.16389/j.cnki.cn42-1737/n.2018.05.002

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The power-voltage（P-U）curve of the photovoltaic（PV）array under uniform illumination is a single peak，and the voltage-current（I-U）curve is a single ladder. When the PV array is covered by clouds，mud，trees，etc.，partial shading occurs in the PV array. The output P-U curve of the PV array have multi-peak values，and multiple steps appear in the I-U curve，resulting in a decrease in the output power of the PV array. The author used Matlab/Simulink to construct the model of the PV array under the shadow condition and carried out several simulations. Some characteristics of the P-U curve and the I-U curve were drawn and their regularities were summarized. The research provided the theoretical basis for maximum power point tracking（MPPT）under shadow conditions.

Optimal Quantity Relationship Between Modeling Group and Prediction Group in Soil Organic Carbon Prediction Model Based on PLSR

DING Jianjun，ZHANG Sheng，SUN Chao，MI Tie

2018, 46(5):  404-408.  doi:10.16389/j.cnki.cn42-1737/n.2018.05.003

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Based on rapid determination technology research of soil organic carbon content in scene, an analysis method of visible and near infrared reflectance spectroscopy for soil samples was proposed. The 400 ～ 1 100 nm band spectrum was pretreated by S-G smoothing and with first order differential filtering，and the prediction model of soil organic carbon was established by partial least squares regression analysis（PLSR）. The results showed when the ratio of the sample number of the modeling group and the sample number of the predicted group was 52∶53（about 1∶1），the determining coefficient was R² =0. 98, and the standard deviation of the root mean square error of calibration was RMSEC = 0. 25. These results indicate when the ratio of the sample number in the modeling group and in the prediction group is set to 1∶1，it is the best condition to establish the prediction model based on PLSR for soil organic carbon.

Preparation，Characterization and Properties of ZnO Quantum Dots-polyimide Membrane

ZHU Tianrong，YU Xiaoyang，WANG Gang，WANG Zeyu，SU Wangtianhui，LU Jingsong

2018, 46(5):  409-414.  doi:10.16389/j.cnki.cn42-1737/n.2018.05.004

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In this paper，polyamide acid（PAA）solution was synthesized by 3，3′，4，4′，- bipheny ltetracarboxylic dianhydride（BPDA）and P-phenylenediamine（PPD）. ZnO and polyamic acid were mixed by solution mixing method. Then ZnO-polyimide（PI） membrane was obtained by gradient heating in muffle furnace. The surface structure，transmittance，thermal stability and crystal structure of the composite membranes were characterized by scanning electron microscopy（SEM），ultraviolet spectrophotometer（UV-Vis），thermogravimetric analyzer（TG）and X-ray diffraction analysis（XRD）. The adsorption properties of nano ZnO-PI and quantum dot ZnO-PI membrane on methyl orange were studied. The results showed that in the 4 mg/L methyl orange solution，the nano ZnO-PI membrane and the quantum dot ZnO-PI membrane had certain adsorption properties.

Recent Research Progress of Fluorescent Probes Based on BODIPY

SHU Tingting，HUANG Wenwen，YANG Zhihui，YU Yanhua

2018, 46(5):  415-425.  doi:10.16389/j.cnki.cn42-1737/n.2018.05.005

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BODIPY is one of the excellent fluorescent dyes and has been widely used in the past twenty years due to its outstanding optical features such as narrow emission peak，relatively high fluorescence quantum yield，high molar absorption coefficient，photo stability，and insensitivity to pH. In this paper，the origin，structure and basic fluorescence properties of BODIPY have been introduced. The progress in the application of fluorescent probes based on BODIPY in the detection of several cations，anions，benzyl thiol and various proteins in the last four years were reviewed through the mechanism analysis.

Microstructures and Properties of Alumina Reinforced Aluminum Matrix Composites

YU Xiaohong，WEI Pengfei，LI Yao，TONG Xingsheng，XUE Ping

2018, 46(5):  426-430.  doi:10.16389/j.cnki.cn42-1737/n.2018.05.006

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Alumina reinforced aluminum matrix composites with different Al2O3 content were prepared with powder metallurgy and vacuum hot pressing sintering. The effects of microstructure and morphology on hardness of the composites were analyzed by X-ray diffraction，metallographic microscope and scanning electron microscopy. The results showed that with the increase of Al2O3 ranging from 1% to 4%，the hardness of the composites increased firstly and then decreased. When Al2O3 remained 2%，the sintering temperature was 400 ℃ and the pressure was 50 MPa，the hardness of the composites reached the highest of 38. 7 HV. It could be found in XRD patterns and metallographic pictures，the increasing hardness was attributed to the addition of Al2O3，which led to refining of the grain size and the microstructure of Al matrix.

Application of Novel Fluorescent Nanomaterials on Detection of Nucleic Acids and Proteins

CHEN Chaohui，ZHANG Zhengtao，SU Lufang

2018, 46(5):  431-437.  doi:10.16389/j.cnki.cn42-1737/n.2018.05.007

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Nucleic acid is very important in genetic information transmission and is closely related to a series of life phenomena such as growth，heredity and variation of living organisms. The variation of protein concentration can reflect the early stages of certain diseases. Therefore，the detection of proteins is valuable in disease diagnosis and genomics. Recently，with the development of nano-biotech? nology，fluorescent nanomaterials have emerged as a powerful tool for establishing new analytical methods due to their low toxicity，easiness of synthesis and low cost. In this review，we introduced the fundamental properties of the new fluorescent nanomaterials and focused on their recent applications on nucleic acid and protein analysis.

Analysis of O-acetylation Modification on Sialylated N-glycans with Dual Modifications and UPLC-MS/MS

FU Xian，ZHANG Qiwei，WU Zhaoguan，ZHENG Qi

2018, 46(5):  438-445.  doi:10.16389/j.cnki.cn42-1737/n.2018.05.008

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The sialylated N-glycans from freshwater crucian carp serum are rich in O-acetylation modification. This article provided an in- depth analysis of the O- acetylation distribution in dual modifications sialylated N-glycans released from the crucian carp serum with UPLC-Orbitrap-MS/MS. Uneven distribution of O- acetylation was identified in sialylated N- glycans isomers. The results enriched the biological information of glycomics of crucian carp. The established method has a wide application prospect in the research of glycan modification and the search for glycoprotein biomarkers.

Effects of Exogenous 2，4-epibrassinolide on Heat Resistance of Peony

REN Zengbin，CHEN Fazhi，SHU Changqing，LI Xiuli，LIU Kehua，JI Xiaomei

2018, 46(5):  446-453.  doi:10.16389/j.cnki.cn42-1737/n.2018.05.009

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In order to study the effects of exogenous 2，4-epibrassinolide on the heat tolerance of peony，the 3-year-old Paeonia ostii ′Fengdan′ container seedlings was taken as materials which treated with 0. 1，0. 5，1. 0，1. 5 mg/L of epibrassinolide through spraying them on the leaves，under the artificial climate simulating the heat stress（40 ℃ /35 ℃，day / night），the related physiological and biochemical indexes and ultrastructure in leaves of Paeonia ostii ′Fengdan′ were determined in the experiment. The experimental results showed that: exogenous epibrassinolide increased net photosynthetic rate and reduced the relative electrical conductivity of leaves of Paeonia ostii ′Fengdan′. The accumulation of malondialdehyde was inhibited effectively and the soluble sugar content was decreased. The content of soluble protein was increased and the superoxide dismutase（SOD）activity was enhanced. The exogenous epibrassinolide could slow down the rate of Paeonia ostii ′Fengdan′ cell damage by the high temperature and let the cells remain relatively intact structure. It could also inhibit the disintegration of cell membrane，the deformation of chloroplast and mitochondrial. Appropriate concentration of exogenous epibrassinolide can enhance the heat resistance of peony， and the concentration of 1. 0 mg/L is the best.

A Meta-analysis of VEGF and CEA as Diagnostic Markers in Malignant Pleural Effusion

CHEN Yao，LU Hongda，QIU Bin

2018, 46(5):  454-460.  doi:10.16389/j.cnki.cn42-1737/n.2018.05.010

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Objective To evaluate the significance of vascular endothelial growth factor（VEGF）and carcinoembryonic antigen（CEA）levels in the pleural fluid for the differential diagnosis of benign and malignant pleural effusion in adult patients. Methods A computer search was carried out with four electronic databases（PubMed，China Zhiwang，Wanfang and VIP）. A total of 12 studies on the value of VEGF and CEA levels for the differential diagnosis of benign and malignant pleural effusion were identified；of which nine met the inclusion criteria were included in the Meta-analysis of this study. Results Stata12.1 data analysis revealed that the level of VEGF in malignant pleural effusion was significantly higher（Z = 8. 04，P = 0. 000 < 0. 05）than that in benign pleural effusion，with an average increase of 1. 92 ng/mL，95% CI（1. 45，2. 39）. The level of CEA in malignant pleural effusion was also significantly higher（Z = 12. 3，P = 0. 000 < 0. 05）than that in benign pleural effusion，withan average increase of 1. 36 ng/mL，95% CI（1. 15，1. 58）. Conclusion The results of this analysis indicate that malignant pleural effusion is associated with higher levels of VEGF and CEA in pleural effusion. The VEGF and CEA levels in the pleural fluid may be valuable biomarkers for the differential diagnosis of benign and malignant pleural effusion.

Safety and Effectiveness of Analgesia Gastroscopy with Different Sedative Methods

LI Ni，HUANG Xiaodong，ZHU Qingxi

2018, 46(5):  461-465.  doi:10.16389/j.cnki.cn42-1737/n.2018.05.011

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Objective To compare the safety and sedative effects of different sedative methods of painless gastroscopy. Methods From February 2017 to April 2017，450 patients taken painless gastroscopy in Wuhan No.3 Hospital were randomly divided into three groups，150 patients in group A（propofol），150 patients in group B（propofol combined with midazolam） and 150 patients in group C（propofol combined with remifentanil）. The heart rate，blood pressure，oxygen saturation changes，uncomfortable reaction，wake-up time and operation time were compared in three groups. Results The vital signs of patients in group B and C were more stable than those in group A（P < 0. 05），and the case number of uncomfortable reaction was significantly lower than that in group A（ P < 0. 05）. The dosage of propofol in group B and C was less than that in group A（ P < 0. 05），and the operation time in the three groups was not statistically significant（ P > 0. 05）. The wake-up time was group C < group B< group A（ P < 0. 05）. Conclusion Propofol combined with midazolam or remifentanil is safe and effective in the treatment of painless gastroscopy. Compared with propofol alone，the combination therapy is more beneficial to patients with stable vital signs and less discomfort，it can reduce the dosage of propofol.

Eight Years Survival of Rectal Cancer with Non-surgical Treatment: a Case Report and Literature Review

FANG Zijian，LI Min，BU Jiajun，GAO Chang，LIU Can，XIE Yarong，FENG Jueping

2018, 46(5):  466-470.  doi:10.16389/j.cnki.cn42-1737/n.2018.05.012

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Objective To investigate the effect of ″wait and observe″ strategy of non-surgical treatment on survival and quality of life in patients with rectal cancer and with clinical complete response（cCR）after neoadjuvant chemoradiotherapy. Methods One case of low rectal cancer with cCR after neoadjuvant chemoradiotherapy without radical surgery has been dynamically monitored for eight years by MRI，colonoscopy，CT，serum CEA，CA-199 and so on. Results The patient received neoadjuvant chemoradiotherapy to achieve cCR had multiple lung metastases in the third year，and received chemotherapy-based comprehensive treatment for five years，has survived for eight years. However，the quality of life was significantly reduced. Conclusion The strategy of non-surgical treatment for cCR after neoadjuvant chemoradiotherapy for rectal cancer should be carefully considered. Distant metastasis is one of the important factors affecting the quality of life and prognosis of patients.

High Performance Liquid Chromatographic Fingerprints of Jieduyihao

LI Can，TANG Lijun，RU Qin，ZHOU Mei，LI Chaoying

2018, 46(5):  471-476.  doi:10.16389/j.cnki.cn42-1737/n.2018.05.013

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Objective The aim of this study is to develop the fingerprints of the Jieduyihao（JDYH） with high performance liquid chromatographic （HPLC） analysis and to provide the basis for the quality control of JDYH. Methods The HPLC fingerprints were conducted with the Ultimate TM XBC18（250 mm × 4. 6 mm）column in gradient elution. The analyses of corydaline，tetrahydropalmatine，berberine and glycyrrhizic acid were conducted with the mobile phase consisted of acetonitrile-waterphosphoric acid，at column temperature 30 ℃，flow rate of 1. 0 mL/min and detective wavelengths of 280 nm. The analyses of ginsenoside Re and ginsenoside Rb1 were conducted with the mobile phase consisted of acetonitrile-water in gradient elution，at column temperature 30 ℃，flow rate of 1. 0 mL/min and detective wavelengths of 203 nm. Results The fingerprints of ten batches of JDYH decoction were established，which contained 19 common peaks，the similarities among different batches were 0. 998， with RSD < 1% . Conclusion The analyses of HPLC fingerprints have high sensitivity and good reproducibility，which can provide a basis for scientific evaluation and quality control of JDYH.

Drug Fever Induced by Levothyroxine Sodium: a Case Report and Literature Review

WU Bin，SHANG Weifeng，DONG Junwu，CAI Yuan

2018, 46(5):  477-480.  doi:10.16389/j.cnki.cn42-1737/n.2018.05.014

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Objective To explore the clinical features of drug fever induced by levothyroxine sodium and to improve the awareness of this adverse drug reaction. Methods The clinical data of one case of drug fever induced by levothyroxine sodium (in Department of Nephrology and Rheumatology，The Fourth Hospital of Wuhan) was analyzed retrospectively，and the related literature was reviewed. Results The levothyroxine sodium was the main reason causing the patient′s fever. Conclusion The clinician and pharmacist should pay more attention to the drug fever caused by levothyroxine sodium in order to decrease the adverse reaction and the unreasonable usage of antibiotics.