Abstract: Advanced cancer pain is mostly moderate to severe pain, and the incidence is high, which is one of the important causes of depression in patients with malignant tumors. Depression may make cancer pain difficult to control and promote tumor progress. In recent years, the reports of treatment on pain with depression in advanced cancer at home and abroad were mainly opioid combined with antidepressant. This article reviewed the diagnosis, evaluation and progress of treatment on pain with depression in advanced cancer, also summarized the insufficiency of current treatment methods, assessment scale and future research directions.

Key words: advanced cancer pain, depression, assessment, opioid, antidepressants