Abstract: Estrogen is mainly secreted by the ovary and regulates a series of downstream gene expressions by binding to the estrogen receptor（ER）, and plays an important role in various tumor formations. The expression of estrogen receptors is detectable in a variety of tumors, such as breast, ovary, lung, colon and prostate cancers; this suggests that the estrogen-signaling pathway is involved in the occurrence of a variety of tumors. A number of epidemiological studies have indicated that man with gastric cancer are about twice as many as women, and this difference disappears after menopause, indicating that estrogen-signaling is involved in the development and progression of gastric cancer. The study of this phenomenon will not only further elucidate the mechanism of estrogen action in gastric cancer, but also provide a novel theoretical basis for the treatment of gastric cancer. This paper reviewed the research progress of relationship of estrogen and gastric cancer.

Key words: estrogen, estrogen receptor, gastric cancer