Abstract: Objective To compare the locking proximal femul plate（LPFP）and proximal femur naill（PFN）in treatment of unstable intertrochanteric fracture of femur. Methods There were 82 patients with unstable intertrochanteric fracture of femur，42 patients were treated with LPFP，40 patients were treated with PFN. The incision length，operation time，intraoperative blood loss，postoperative drainage，clinical healing time of fracture ，post operative complications and the excellent and good rate in Harris score were recorded. Results There was significant difference between the two groups in the incision length，operation time，intraoperative blood loss，postoperative drainage，postoperative complication s（P < 0. 05）. The LPFP group incision length，operative time，intraoperative blood loss，postoperative drainage，post operative complications were higher than those of the PFN group.There was no significant difference between the two groups in the clinical healing time of fracture and the excellent and good rate in Harris score（ P > 0. 05）. Conclusion In the treatment of unstable intertrochanteric fracture of the femur ，the LPFP group has a longer incision，longer operation time，more bleeding，more postoperative complications and higher postoperative complications than PFN group. In the treatment of unstable intertrochanteric fractures should be carefully used and here recommends the PFN. But for medullary cavity is too small，and patients with larger femur anterior arch curve，LPFP is preferred.