Abstract: Objective To compare the differences of endometrium transplantation at abdominal wall and intestinal loop on making endometriosis rat model，aimed to find a reliable method for endometriosisbased study. Methods 11 adult female SD rats were anesthetized by 10% chloral hydrate. Endometrium tissues were stitched to abdominal wall and mesentery with absorbable suture silk. Survival and growth of transplanted endometrium were checked four weeks later. Results The volume of grafts increased significantly，dark red or translucent vesicles indicated that the model was made successfully. 1 rat died within 1 week after surgery. 65% of grafts survived on the abdominal wall，which was significantly lower than transplanted on the mesentery（95%）， P < 0. 05. There is no difference between the volume of endometrium on abdominal wall （35. 53 ± 22. 58）mm³ and mesentery （90. 29 ± 74. 93）mm³. Conclusion Endometrium transplanted to mesentery is beneficial for endometrium survival and growth，which can be used for endometriosis-based animal study.

Key words: endometriosis, survival rate, growth condition