Abstract: Objective To develop the ganciclovir oral disintegrating tablet and evaluate the clinical utility. Methods Using ganciclovir as raw material medicine to develop orally disintegrating tablet，controlling the quality with ultraviolet spectrophotometric method and HPLC method，applying for the treatment of AIDS patients complicated with cytomegalovirus retinitis. Results The characters，identification，inspection，content determination indexes meet the quality control requirement，the effective rate for the curative treatment of AIDS patients with cytomegalovirus retinitis was 85. 71%.Conclusion The anciclovir oral disintegrating tablet developed had stable quality，and the quality analysis method is feasible. The adjuvant treatment of AIDS complicated with cytomegalovirus retinitis has obvious effect.

Key words: ganciclovir , oral disintegrating tablet, clinical application