Abstract: With the continuous deepening of the reform of medical system，the importance of the prepayment system of single disease is increasing. Establishment of payment standard of disease should be based on clinical pathway and lay the foundations on the social average medical cost and calculate the payment standard of each disease accurately. By the application of clinical pathway in fees combined with the electronic medical record， the medical process is optimized. The implementation of the system of single disease prepayment can make a more reasonable and scientific pricing，effectively improve the quality of medical management，standardize the nursing service，reduce the medical expense，enhance the core competitiveness of the hospital and provide an effective way to solve the problem of "seeing a doctor is difficult and the fee is expensive" for the common people.The implementation of the management of single disease is the current hospital management direc?tion and inevitable trend.

Key words: clinical pathway, single disease cost, direct cost, indirect costs, electronic medical records