Abstract: Objective To study the relation between the chronic obstructive pulmonary disease（COPD）with anemia and inflammation. Methods According to the anemia standard，the 273 cases of AECOPD were enrolled. 40 cases of anemia in COPD （anemia group）and 40 cases of non-anemic in COPD（non-anemia group）were selected. Lung function（FEV1％），and interleukin-6（IL-6），interleukin-8（IL-8），and tumor necrosis factor-α（TNF-α）were determined，and the count of CD4 ⁺ and CD8 ⁺ T cell were measured with flow cytometry. The correlation was studied. Results The level of interleukin-6（IL-6），interleukin-8（IL-8），and tumor necrosis factor-α（TNF-α） were significantly higher in anemia group than in non-anemic group （P< 0.05） . The ratio of CD4 ⁺ /CD8 ⁺ in anemia group were significantly lower than non-anemic group （P< 0.05） . Conclusion COPD with anemic may be related inflammation.

Key words: chronic obstructive pulmonary disease（COPD）, anemia, inflammation, IL-6, IL-8, TNF-α, CD4 ⁺ /CD8 ⁺