Abstract: Expounds the implementation of "project responsibility system" teaching mode in basic biology experiments，discusses the problems existing in the implementation process of "project responsibility system" and the matters needing attention. With implementation of the model ，reflects the teaching ideas and concepts which are teachers as lead，students as the main body ，cultivates the students′ experiment ability，thinking ability，the ability to analyse and solve problems，scientific research ability and team cooperation spirit，improves the teaching quality and effect.

Key words: basic biological experiment, project responsibility system, teaching mode