Abstract: Objective：To investigate the medication for non-hospitalization chronic rhino-sinusitis patients and provided a basis to improve the safety of medication. Methods：200 patients were investigated with the self-designed questionnaire. Results：The medicine mostly used in rhinosinusitis patients listed as follows：anti-inflammatory，antibacterial，antihistamines，Chinese patent drug，decongestants，etc. 85% patients took medication following the doctor′s advice at home，71% patients with symptom did self-medication，36% patients read the instructions carefully before use，31% patients regularly checked the expiry date，45% patients with the discomfort would seek medical help during the treatment. Conclusion：Patients with rhino-sinusitis do not fully understand the knowledge of medication，there is hidden danger in medication，it needs to strengthen the patients and their caregivers medication knowledge education，makes them master the medication self-management knowledge and reasonable medication.