Abstract: Objective：Objective：To investigate the diffent efficacy of standard dose Rosuvastatin and Simvastatin in patients with unstable angina pectoris. Methods：Chosed 80 patients with unstable angina pectoris diagnosed by coronary artery angiography in the affiliated hospital of Jianghan University from January 2011 to December 2012 and divided into A group（40 patients）and B group（40 patients）in randomized controlled methods，A group taken Rosuvastatin 10mg once daily，B group taken Simvastatin 40mg once daily，to compare the remission rate of angina pectoris and the effect of blood-fat regulating after treatment of eight weeks. Results：（1）The Rosuvastatin group（92.5%）has higher total clinical remission rate than Simvastatin group（86. 7%）（P< 0.05）.（2）The two groups have lower total cholesterol（TC）and low density lipoprotein cholesterin（LDL-C）than those before the treatment（P< 0.05）. The Rosuvastatin group have higher reduction rate of TC and LDL-C than Simvastatin group（P< 0.05）. Conclusion：Rosuvastatin is superior to Simvastatin in patients with unstable angina pectoris.