Abstract: Objective：To investigate the efficacy and safety of continuous magnesium sulphate intravenous infusion for treatment of severe tetanus of adults. Methods：The clinical data of 52 cases of severe tetanus from May 2000 to August 2010 in the Department of General Surgery of the Affiliated Hospital of Jianghan University were analysed retrospectively，the group treated with magnesium sulphate was 27 cases，and the group treated without magnesium sulphate was 25 cases. Results：2 cases died，and the left 50 cases were cured，and in the group treated with magnesium sulphate，the dosage requirement for sedatives reduced，the rate of using ventilatory support reduced，the complications reduced，and mean total expense reduced. Compared the two groups，the differenc was statistically significant（P < 0.05），the difference of mean hospital stays had no statistical significance （P>0.05） . Conclusion：Magnesium sulphate therapy can control the symptom of severe tetanus effectively，and reduce the dosage requirement for other sedatives，reduce the used of mechanical ventilation，simplify nursing care，reduce the complications，the total expenses are low，and administra? tion is convenient.