Abstract: ObjectiveTo survey serum uric acid单位 UA), cystatin C单位 Cys C) and creatinine单位 Cr) levels in patients with essential hypertension单位 EH), and study its clinical significance. MethodsUA and Cr were measured by enzymatic method with automatic biochemistry analyzer,Cys C was measured by nephelometry with specific protein aparatus. Results88 cases were accompanied with hyperuricemia 单位 HUA) in 200 patients with EH. Their mean Cys C value单位 1.12±0.14) mg/L and mean Cr value单位 141.5±93.5) μmol/L were higher than those in the patients without HUA significantly单位 P＜0.05), and increased with the growth of age and stages of hypertension. However, the rising rate of Cr value was lower than Cys C and HUA incidence单位 P＜0.05). ConclusionCys C and Cr values have close relation with HUA in patients with EH. UA and Cys C values rise before Cr value. UA is an early manifestation of impairment of renal function in patients with EH.

Key words: essential hypertension, uric acid, creatinine, cystatin C