Abstract: ObjectiveTo compare the influence of 3 kinds of walnut-meat extractive on IL－1, IL－6 content in brains in AD rats. MethodsInjected Aβ1－40 to nucleus basalis of Meynert to establish AD model, treated with walnut-meat water extractive, walnut-meat alcohol extractive and walnut-meat acetone extractive for continuous intragatric administration, and were contrast with blank group, sham opeation group and model set group. ResultsThe IL－1, IL－6 content in model set group was marked higher than that in blank group and sham opeation group, the walnut-meat water extractive, alcohol extractive, acetone extractive all could down-regulate the content单位 P＜0.01), while down-regulad IL－6 content, the effect of acetone was the best, and P＜0.05 for comparasion of three extractives. ConclusionThe walnut-meat extractive can effectively down-regulate the content of inflammatory factors IL－1, IL－6, so as to down-regulate the toxicity of Aβ to prevent and cure AD. The effect of acetone extractive is the best.

Key words: walnut-meat extractive, Alzheimers′ disease单位 AD), IL－1, IL－6