Effects of Alcohol on Induction of Long-term Potentiation in Lateral Perforant Path-CA3 Area of Rats

Journal of Jianghan University(Natural Science Edition) ›› 2011, Vol. 39 ›› Issue (2): 66-69.

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Effects of Alcohol on Induction of Long-term Potentiation in Lateral Perforant Path-CA3 Area of Rats

YANG Rong, YANG You-hua, CHEN Xiao-qing, HUANG Dan

Department of Physiology, School of Medicine, Jianghan University, Wuhan 430056, Hubei, China

Received:2011-01-12 Online:2011-03-20 Published:2013-12-30

Abstract

Abstract: Objective: To investigate the effect of alcohol on the induction of long-term potentiation(LTP)in lateral perforant pathway(LPP)-CA3 area of rats and its possible mechanism.Methods Taking the method of electro-physiology record in vivo, through micro-injection of alcohol,naloxone and bicuculline respectively to hippocampal CA3 area, using the slope coefficient chang of field excitory postsynaptic potentials(fEPSP) as index,to observe the LTP induction change caused by high frequency stimulation.Results (1) Single application of alcohol into CA3 area inhibited the induction of LTP in a dose-dependent manner.(2)Micro-injection of naloxone or bicuculline before administration of alcohol into CA3 area partially reduced the inhibitory effect of alcohol on the induction of LTP.ConclusionThe inhibition of alcohol on the induction of LTP in hippocampal CA3 area may be mediated by GABA energic system and endogenous opium system.

Key words: alcohol, long-term potentiation(LTP), naloxone, field excitory postsynaptic potentials, bicuculline, lateral perforant path(LPP)

CLC Number:

R338.11

YANG Rong, YANG You-hua, CHEN Xiao-qing, HUANG Dan. Effects of Alcohol on Induction of Long-term Potentiation in Lateral Perforant Path-CA3 Area of Rats[J]. Journal of Jianghan University(Natural Science Edition), 2011, 39(2): 66-69.

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Effects of Alcohol on Induction of Long-term Potentiation in Lateral Perforant Path-CA3 Area of Rats

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