Abstract: Objective To investigate the effect of neoadjuvant chemotherapy on tumor markers levels in cervical cancer and to explore the role of tumor markers in the evaluation of neoadjuvant chemotherapy. Methods The clinical data of 40 patients received chemotherapy and radical surgery of cervical cancer in Wuhan Central Hospital were retrospectively analyzed. The size of the masses before and after neoadjuvant chemotherapy was determined with abdominal ultrasound and magnetic resonance imaging，and the lymph node metastasis around the uterus was determined with the pathological results of lymphocyte. Tumor markers levels（carcino-embryonic antigen（CEA），carbohydrate antigen 125（CA125），squamous cell carcinoma antigen（SCC-Ag））before and after two rounds of neoadjuvant chemotherapy and radical cervical cancer surgery were compared to evaluate the correlation between the efficacy of neoadjuvant chemotherapy and the levels of tumor markers of cervical cancer. Results The levels of tumor markers in cervical cancer decreased significantly after chemotherapy and surgery，the differences were statistically significant（CEA：F = 11. 07，P ＜ 0. 05；SCC-Ag：F = 8. 84，P ＜ 0. 05；CA125：F = 10. 18，P ＜ 0. 05 ）. Neoadjuvant chemotherapy reduced the ratio of locally advanced cervical cancer（ χ2 = 7. 17，P < 0. 05）. After neoadjuvant chemotherapy，the tumor markers levels in the patients whose tumor diameter shrunk ≥ 1 cm were lower than those shrunk <1cm，and the difference of the level of squamous cell carcinoma antigen was statistically significant（t = 2. 4，P < 0. 05）. However，the levels of tumor markers after chemotherapy could not reflect the lymphatic metastasis of patients. Conclusion Neoadjuvant chemotherapy can significantly reduce the levels of tumor markers，the serum tumor markers are indicators for the effectiveness of neoadjuvant chemotherapy.

Key words: cervical cancer, serum tumor markers, neoadjuvant chemotherapy, CEA, CA125, SCC-Ag