Abstract: The design and implementation of the simulation system of traditional Chinese medicine decoction pieces are based on virtual reality technology，and collision detection is one of the key technologies to realize the virtual reality. The processing simulation system of Chinese herbal pieces is designed with the algorithm based on the maximum pixel segmentation，which is improved by AABB bounding box collision detection algorithm. The experimental results show that the bounding algorithm based on the maximum pixel segmentation reduces the error of collision detection，and improves the immersion of human computer interaction in simulation system.

Key words: Chinese herbal pieces, simulation system, collision detection, maximum pixel segmentation, virtual reality technology