Abstract: Objective To analyse the possibility of natural infected area of scrub-typhus in Enshi district，and explore the advantage of utilization of levofloxacin to scrub-typhus in the situation of strict control and deficiency of antibiotics. Methods Retrospectively reviewed the clinical data and treatment of two cases infected by scrub-typhus in the Xianfeng County People′s Hospital in Oct.，2014. Results The two cases were a couple，both had fever，rashes and typical eschar. They lived in mountainous area surrounded by many weeds and once worked in a vegetable garden. After one week of outbreak of disease，the antibody titers of the strain were OXk 1∶160，the couple was diagnosed as scrub-typhus infection and it was effective with levofloxacin. Conclusion Enshi district is not a natural infected area of scrub-typhus，but the adjacent Xiangxi Tujia Autonomous Prefecture is an important infected area of scrub-typhus，and the area has similar geography，climate and plants with Enshi district，so Enshi district maybe another infected area. It needs further epidemiological investigation to confirm the infected area attribute，and to know the distribution of Oriential tsutsugamushi in tick pests and rodents.

Key words: scrub-typhus, family clustering, infected area, Enshi district