Abstract: Objective：Chooses two chlorinated paraffins products which contain different content of short chain chlorinated paraffins（SCCP）as model compound（CPsⅠ，38.22% and CPsⅡ，0.08%），compares their influence on SD male rats after continuously 14 days being exposed through oral intragastric administration，according to that，to explore whether there is special toxicity of SCCP or not.Methods：The exposing concentration are 10，50， 100 （CPsⅠ），100 （CPsⅡ）mg/kg，respectively. Results：After being exposed under two chlorinated paraffins，there is no obvious influence on food intaking and weight. CPsⅠ and CPsⅡ acute exposing，can cause hepatocyte swelling，hydropic degeneration，cytoplast loosen；and renal tubule swelling，glomerulus atrophy，glomerulus hyalinosis；and alveolar septum incrassation，inflammatory cell infiltration；and so on histopathology changes. Conclusion：Acute chlorinated paraffines exposing has toxicity to SD male rats，the effect has no significant relationship with the content of SCCP.