Abstract: ObjectiveTo analyse the drug resistance rate of Pseudomonas aeruginosa in the Affiliated Hospital of Jianghan University, to provide direction for clinical drug application. Methods: To analyse the drug resistance of 138 cases which clinically isolated Pseudomonas aeruginosa from Jan., 2009 to Dec., 2010, and obtained the rate of antibiotic-resistance by WHONET5.4 software. Results: The highest detection rate of Pseudomonas aeruginosa came from the specimen of respiratory tract, which was 86.9%; These Pseudomonas aeruginosa were more sensitive to amikacin(87.0%)、sulbactam and cefopcrazone(83.8%),cefepime(79.4%), and then to ceftazidime(76.3%),aztreonam(68.5%); the resistance rates of Pseudomonas aeruginosa to cefotaxime(86.4%),levofloxacin(32.8%)were higher than other antibiotics. Conclusion:For the special drug-fast mechanism of Pseudomonas aeruginosa and the wide use of the broad-spectrum antibiotic, the resistance rate of Pseudomonas aeruginosa to antibiotic is higher and higher, and there are samples of Pseudomonas aeruginosa which are multi-drug-resistance, the infection always can not be cured by single antibiotic. The most effective method for preventing the fast development of resistance of Pseudomonas aeruginosa to antibiotic is early drug combination, strengthening the monitoring to the resistance rate of Pseudomonas aeruginosa, and analysis of drug sensitive test.

Key words: Pseudomonas aeruginosa, rate of antibiotic-resistance, infection, superbacterium, New Delhi metallo-beta-lactamase-1(NDM-1), antibiotic, drug combination