Abstract: Objective To evaluate the effect of acupuncture combined with nucleolide and casein injection at Xinwu acupoint on patients with perennial allergic rhinitis. Methods 95 patients with allergic rhinitis were randomly divided into treatment group（n = 47），treated with acupuncture combined with nucleolide and casein injection at Xinwu acupoint；and control group（n = 48），treated with oral dispersion of cetirizine hydrochloride. Two weeks are a course of treatment for two courses. Serum related factors: IgE，histamine（HIS），interleukin 4 （IL-4） levels and rhinoconjunctivitis quality of life scale （RQLQ） scores were compared between the two groups. Results ① The levels of serum IgE，HIS and IL-4 in the two groups decreased after treatment，the difference in the two groups was statistically significant（P < 0. 05）. The decrease in the treatment group was significantly greater than that in the control group，it was statistical significance （P < 0. 05）. ② The scores of RQLQ in the two groups were significantly lower after treatment，the difference in the groups was statistically significant（P < 0. 05）. The difference between the two groups was statistically significant（P < 0. 05）. ③ The efficacy was compared，the effective rate of the treatment group was 89. 36%，which was significantly higher than that of the control group （50. 08%）， the difference was statistically significant. Conclusion Compared with the treatment of cetirizine hydrochloride dispersible tablets， acupuncture combined with nucleolide and casein injection at Xinwu acupoint can significantly improve quality of life and relieve inflammation of patients with allergic rhinitis.

Key words: perennial allergic rhinitis, Xinwu acupoint, nucleolide and casein injection, serum related factors, life scale RQLQ