Abstract: Objective To study the abnormal rate and influential factors of serum alanine aminotransferase（ALT）results in university freshmen. Methods The author conducted physical examination for 4 393 university students enrolled in 2015，also calculated their serum ALT abnormal rate and revealed its influential factors. Results The gross abnormal detection rate was 6. 65%，which was 11. 06% for men and 2. 78% for women，respectively. The former was substantially higher than latter ( χ² =120. 801，P < 0. 01）. The abnormal detection rate was 6. 08% for local students and 8. 62% for students from other provinces. In other words，the former was apparently lower than the latter（ χ² = 7. 982，P < 0. 01）.According to the analysis results，the most prominent contributing factor was obesity（56. 51%），which was followed by hyperuricemia（44. 18% ）. The third factor was the HBsAg- positive（10. 62% ）.Conclusion The ALT abnormal rate is related to gender，body mass index，area of origin students，hyperuricemia and hepatitis B infection.

Key words: university freshmen, physical examination of university freshmen, serum alanine amino?transferase（ALT）