Abstract: Improvement of experimental teaching is not only important to train medical students for their ability to practice and to innovate，but also an important goal of experiment teaching reform in medical colleges and universities. Aimed to improve the teaching efficiency and quality of the experiment teaching and cultivate talents with innovation and practice abilities，we integrated the experimental contents of three courses （including medical microbiology， medical parasitology， and medical immunology）into one independent new course，named pathogenic biology and immunology integrative experiment （MIMP） for students in clinical medicine speciatty. We adjusted the undergraduate education plan，integrated the experimental contents，rewrote the experimental textbooks，recombined the experimental teaching resources and enriched the teaching staff， reformed the experimental teaching methods and means，and innovated the examination system and course evaluation system. Therefore，we constructed and practiced the MIMP integrative experimental system，and the system works well with a perfect effect.

Key words: pathogenic biology and immunology integrative experiment（MIMP）, experiment teaching system, educational reform, clinical medicine speciatty