Abstract: Objective To explore the clinical characteristics of hyperdense cerebral artery sign，evaluate the safety and efficacy of hyperdense cerebral artery sign treated with intravenous thrombolysis. Methods Retrospectively analyzed the clinical data and follow-up results of 15 cases that were found out having hyperdense cerebral artery sign with CT and having neurological deficit symptoms，and the 15 cases were treated with intravenous thrombolysis. Among the 15 cases，5 were treated with urokinase and 10 were treated with alteplase（rt-PA） . Results After thrombolysis，re-examined with CT，CTA and MRA angiography followed up in 7 cases，DSA angiography followed up in 4 cases，follow-up time was 3 to 18 months，average 10.4 months. The clinical symptoms of all the patients are different degree improved，there were not infarction and hemorrhage happened again. Conclusion The hyperdense cerebral artery sign treated with intravenous thrombolytic therapy can improve the clinical symptoms，and the safety is good.

Key words: hyperdense cerebral artery sign, alteplase； urokinase, intravenous thrombolysis