Abstract: Objective To observe the effects of dexmedetomidine to anesthesia laparoscopic surgery on postoperative recovery phase CO2 accumulation in patients. Methods Chose patients undergoing laparoscopic operation. Before the end of operation about 40 min measured arterial blood gas. Selecting 40 cases of patients with PaCO2 70-90mmHg and pH<7. 30. They were randomly divided into a control group（group N）and dexmedetomidine group（group D） with 20 cases in each. Before the end of operation about 30 min. N group were treated with 0. 9% sodium chloride 10 mL slow intravenous injection. D group were given the dexmedetomidine dubbed 4 μg/mL slow intravenous with dose concentration 0.8 μg/kg. Recorded two groups of patients at extubation（T0），5 min after extubation（T1），30 min after extubation（T2）of heart rate，blood pressure and Riker score. Two groups of patients from extubation to can returned to the ward satisfaction time（T3）. Results Compared the group D with N，at T0，T1，T2 time，heart rate，blood pressure，and Riker scores were statistically significant（P <0. 05）. Comparison of the two groups was not statistically significant from extubation begin to restore satisfactory and could return to ward（P> 0. 05）. Conclusion Laparoscopic surgery，CO2 accumulation in patients with hypercapnia recovery phase of anesthesia，given dexmedetomidine is safe and effective.