Abstract: ObjectiveTo explore the clinical manifestations， diagnosis and treatment of POEMS syndrome. Methods The clinical manifestation，laboratory examination，diagnosis and treatment of patients with POEMS syndrome were reported and reviewed in literature. Results The patient had bilateral legs numbness， M protein， sclerosing bone disease，elevated serum VEGF，splenomegaly，multiple serous effusion，changes in sex hormones，skin pigmentation，and pale nails，which met the diagnostic criteria of POEMS syndrome. The patient achieved good results with the treatment regimen of bortezomib combined with dexamethasone. Conclusion The misdiagnosis rate and missed diagnosis rate of POEMS syndrome are high. There is no uniform treatment plan at present. Early diagnosis is important to improve the survival rate and quality of life of the patients.

Key words: POEMS syndrome, multiple peripheral neuropathy, serum VEGF, bortezomib, case report