中性粒-淋巴细胞比值评估新型冠状病毒肺炎预后的价值

doi:10.16389/j.cnki.cn42-1737/n.2020.06.004

江汉大学学报（自然科学版） ›› 2020, Vol. 48 ›› Issue (6): 33-37.doi: 10.16389/j.cnki.cn42-1737/n.2020.06.004

• COVID-19药理与临床 • 上一篇下一篇

中性粒-淋巴细胞比值评估新型冠状病毒肺炎预后的价值

尚伟锋^a，李园园^b，宋小红^a，杜兴国^a，董骏武^*a，田明^a

武汉市第四医院华中科技大学同济医学院附属普爱医院 a. 肾内科；b. 呼吸内科，湖北武汉 430033

出版日期:2020-12-28 发布日期:2020-12-18
作者简介:尚伟锋(1988— )，男，住院医师，硕士，研究方向：慢性肾脏病一体化治疗。
基金资助:
DONG Junwu

Assessment Value of Neutrophil-to-Lymphocyte Ratio for Prognosis in Coronavirus Disease 2019

SHANG Weifeng^a，LI Yuanyuan^b，SONG Xiaohong^a，DU Xingguo^a，DONG Junwu^*a，TIAN Ming^a

a. Department of Nephrology；b. Department of Respiratory Medicine，Wuhan Fourth Hospital；Puai Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430033，Hubei，China

Online:2020-12-28 Published:2020-12-18
Contact: 董骏武

摘要/Abstract

摘要： 目的 探讨中性粒-淋巴细胞比值（neutrophil-to-lymphocyte ratio，NLR）对新型冠状病毒肺炎（coronavirus disease 2019，COVID-19）患者预后评估的价值。方法 采用回顾性研究的方法，选择收治的399 例COVID-19 为研究对象，根据临床预后，分为生存组（375 例）和死亡组（24 例），收集患者入科第1 天中性粒细胞计数、淋巴细胞计数以计算NLR，比较中性粒细胞、淋巴细胞、NLR 在不同组间的差异；采用受试者工作特征（ROC）曲线评价NLR 预测预后的最佳阈值。结果 死亡组的中性粒细胞、NLR 明显高于生存组，死亡组的淋巴细胞计数明显低于生存组。通过ROC 曲线分析发现中性粒细胞、淋巴细胞、NLR 的ROC 曲线下面积分别为0. 759、0. 838、0. 856，最佳工作点分别为4. 955 × 10⁹/L、0. 775 × 10⁹/L、6. 919。结论 NLR 可以作为一个简便有效的辅助指标用于COVID-19 患者的预后评估。

关键词: 新型冠状病毒肺炎, 新冠肺炎, 中性粒-淋巴细胞比值, 预后

Abstract: Objective To explore the assessment value of neutrophil-to-lymphocyte ratio （NLR） for prognosis in coronavirus disease 2019 （COVID-19）. Methods Using the retrospective study，399 cases of COVID-19 admitted to Wuhan Fourth Hospital were selected as the research subjects. According to the clinical prognosis，they were divided into the survival group （n = 375） and the death group （n = 24）. The neutrophil count and lymphocyte count of patients on the first day of admission were collected to calculate the NLR，and the differences between neutrophils，lymphocytes and NLR in different groups were compared. The receiver-operating characteristic（ROC） curve was used to evaluate the optimal threshold of NLR for predicting prognosis. Results The neutrophils and NLR of the death group were significantly higher than that of the survival group， and the lymphocytes of the death group were significantly lower than that of the survival group. According to ROC curve analysis， the areas under the ROC curve of neutrophils，lymphocytes and NLR were 0. 759， 0. 838 and 0. 856， respectively， and the optimal thresholds were 4. 955 × 10⁹/L，0. 775 × 10⁹/L，and 6. 919，respectively. Conclusion NLR can be used as a simple and effective auxiliary indicator for prognostic evaluation of COVID-19 patients.

Key words: coronavirus disease 2019 （COVID-19）, novel coronavirus pneumonia, neutrophil-to-lymphocyte ratio, prognosis

中图分类号:

R563.14

尚伟锋，李园园，宋小红，杜兴国，董骏武，田明. 中性粒-淋巴细胞比值评估新型冠状病毒肺炎预后的价值[J]. 江汉大学学报（自然科学版）, 2020, 48(6): 33-37.

SHANG Weifeng，LI Yuanyuan，SONG Xiaohong，DU Xingguo，DONG Junwu，TIAN Ming. Assessment Value of Neutrophil-to-Lymphocyte Ratio for Prognosis in Coronavirus Disease 2019[J]. Journal of Jianghan University (Natural Science Edition), 2020, 48(6): 33-37.

[1]	王翔，范铭，陈长燕，戢丕龙，梁凯桦，冯凌雁. 新冠疫情背景下江汉大学学生防控意识和学习现状的调查分析[J]. 江汉大学学报（自然科学版）, 2022, 50(3): 57-64.
[2]	张倩倩，张建军. ABC 评分在肝硬化食管胃底静脉曲张出血患者预后评价中的应用[J]. 江汉大学学报（自然科学版）, 2022, 50(2): 58-63.
[3]	殷紫薇，朱虹，凃乾. 474例新冠住院患者临床特征及重症危险因素分析[J]. 江汉大学学报（自然科学版）, 2021, 49(2): 5-11.
[4]	刘军，程平，方登攀，朱涛. 隐睾混合型生殖细胞肿瘤1 例并文献复习[J]. 江汉大学学报（自然科学版）, 2020, 48(5): 59-64.
[5]	刘文，赵建国，张应天，崔军凯. 腋窝淋巴结转移对浸润性乳腺癌预后的影响[J]. 江汉大学学报（自然科学版）, 2013, 41(1): 88-90.
[6]	余建国. 颅内血肿术后继发对侧迟发血肿[J]. 江汉大学学报（自然科学版）, 2007, 35(1): 79-80.

中性粒-淋巴细胞比值评估新型冠状病毒肺炎预后的价值

Assessment Value of Neutrophil-to-Lymphocyte Ratio for Prognosis in Coronavirus Disease 2019

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 6

编辑推荐

Metrics

本文评价