关键词: 心肌淀粉样变性, 分型, 诊断, 治疗

Abstract: Cardiac amyloidosis is a kind of disease which results from deposition misfolded protein fragments on myocardial extracellular matrix. These protein may derive from monoclonal immunoglobulin, transthyretin (TTR), etc. The manifestations of patients with cardiac amyloidosis may perform as valvulopathy, cardiomyopathy, heart failure and various kinds of arrhythmia etc. In spite of multitudinous noninvasive diagnostic methods, myocardial biopsy remains the gold standard in the diagnosis of cardiac amyloidosis. Actually, the previous treatments focus on improving the symptoms of heart failure and arrhythmia, at present, advanced chemotherapy regimens, immune therapy, stem cell transplantation, regulation of gene expression and more progressive methods are rising up. This paper describes the new research progress of diagnosis, treatment of myocardial amyloidosis.

Key words: cardiac amyloidosis, classification, diagnosis, treatment