关键词: 炎症, 肿瘤, 抗炎药物

Abstract: The inflammatory response not only induces the initiation of tumor，but also promotes tumor development and metastasis. Recent data have shown that inflammation， especially chronic inflammation，induces ROS production and consequently causes oxidative stress response，resulting in DNA damage and repair- inhibition after cellular damage. The accumulation of damage can induce mutations in tumor suppressor genes and finally cause tumorigenesis. Meanwhile，there are many inflammatory cells and inflammatory factors in the tumor micro-environment，induce angiogenesis and tumor progression through up-regulation of the expression of multiple cytokines and chemokines. In addition，some drugs targeting the tumor micro-environment have been shown to be effective in tumor treatments，indicating that inflammation is closely related to tumor occurrence and development. This review summarizes the relationship between inflammation and tumor，with the aim of providing a new treatment option for tumor.

Key words: inflammation, tumor, anti-inflammatory drug