ALDH1 在乳腺癌及乳腺癌癌旁组织中的表达及临床病理意义

doi:10.16389/j.cnki.cn42-1737/n.2021.06.009

江汉大学学报（自然科学版） ›› 2021, Vol. 49 ›› Issue (6): 72-77.doi: 10.16389/j.cnki.cn42-1737/n.2021.06.009

ALDH1 在乳腺癌及乳腺癌癌旁组织中的表达及临床病理意义

余丽颖，詹欣雨，曾思羽，陈明付，高欢，陈琼霞，陈莹，镇鸿燕^*

江汉大学医学院，湖北武汉 430056

发布日期:2021-12-17
通讯作者: 镇鸿燕
作者简介:余丽颖（1996— ），女，硕士生，研究方向：肿瘤病理。

Expression and Clinicopathological Research of ALDH1 in Breast Cancer and Breast Cancer Adjacent Tissues

YU Liying，ZHAN Xinyu，ZENG Siyu，CHEN Mingfu，GAO Huan，CHEN Qiongxia，CHEN Ying，ZHEN Hongyan^*

School of Medicine，Jianghan University，Wuhan 430056，Hubei，China

Published:2021-12-17
Contact: ZHEN Hongyan

摘要/Abstract

摘要： 目的 探讨乙醛脱氢酶1（aldehyde dehydrogenase 1，ALDH1）在乳腺癌及癌旁组织中的表达及临床病理意义。方法 收集71 例患者乳腺癌组织及29 例患者乳腺癌癌旁组织，应用免疫组织化学Envision 法进行ALDH1 检测，并结合肿瘤临床病理特征进行分析。结果 乳腺癌癌旁组织表达主要定位于细胞核中；乳腺癌癌细胞表达主要定位于细胞浆中，部分癌组织呈散在表达，部分癌组织呈弥漫表达。T1 ~ T2 分期肿瘤ALDH1 阳性率51. 9%，明显高于T3 分期的23. 5%。组织学分级I级ALDH1 阳性率为75. 0%，明显高于III 级的55. 6%。腋窝淋巴结转移患者ALDH1 阳性率为42. 1%，明显高于无转移患者的30. 0%。结论 ALDH1 的表达定位差异可能成为判断乳腺肿瘤良恶性标记物；ALDH1 的表达可能与肿瘤的生长、分化及侵袭存在一定相关性。

关键词: 乳腺癌, ALDH1, 肿瘤干细胞, 临床病理

Abstract: Objective To investigate the expression and clinicopathological significance of aldehyde dehydrogenase 1 （ALDH1） in breast cancer tissues and its adjacent tissues. Methods Breast cancer tissues of 71 cases and adjacent tissues of 29 cases were collected，and ALDH1 was detected by immunohistochemical Envision method and the clinicopathological features of the tumor were analyzed. Results The expression of adjacent tissues of breast cancer was localized in the nucleus and the expression of breast cancer tissues was localized in the cytoplasm. Some cancer tissues showed scattered expression，and others were diffusely expressed. The positive rate of ALDH1 in T1-T2 tumors was 51. 9%，which was significantly higher than that in T3 tumors（23. 5%）. The positive rate of ALDH1 in histological grade I tumors was 75. 0%，which was significantly higher than that in grade III tumors （55. 6%）. The positive rate of ALDH1 in patients with axillary lymph node metastasis was 42. 1%，which was significantly higher than that in patients without metastasis （30. 0%）. Conclusion The difference in the positivity of ALDH1 expression may be a marker of benign and malignant breast tumors. The expression of ALDH1 may be correlated with tumor growth，differentiation，and invasion.

Key words: breast cancer, ALDH1, tumor stem cells, clinical pathology

中图分类号:

R737.902

余丽颖，詹欣雨，曾思羽，陈明付，高欢，陈琼霞，陈莹，镇鸿燕. ALDH1 在乳腺癌及乳腺癌癌旁组织中的表达及临床病理意义[J]. 江汉大学学报（自然科学版）, 2021, 49(6): 72-77.

YU Liying，ZHAN Xinyu，ZENG Siyu，CHEN Mingfu，GAO Huan，CHEN Qiongxia，CHEN Ying，ZHEN Hongyan. Expression and Clinicopathological Research of ALDH1 in Breast Cancer and Breast Cancer Adjacent Tissues[J]. Journal of Jianghan University (Natural Science Edition), 2021, 49(6): 72-77.

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ALDH1 在乳腺癌及乳腺癌癌旁组织中的表达及临床病理意义

Expression and Clinicopathological Research of ALDH1 in Breast Cancer and Breast Cancer Adjacent Tissues

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