中药方剂敏脱乐配合火针治疗慢性湿疹疗效观察及作用机制探讨

doi:10.16389/j.cnki.cn42-1737/n.2022.06.008

江汉大学学报（自然科学版） ›› 2022, Vol. 50 ›› Issue (6): 69-80.doi: 10.16389/j.cnki.cn42-1737/n.2022.06.008

中药方剂敏脱乐配合火针治疗慢性湿疹疗效观察及作用机制探讨

王胜强¹，皮先明²，李凯³，詹黎^*4

1. 华中师范大学医院皮肤科/中西医结合科，湖北武汉 430079；2. 湖北省中医院皮肤科，湖北武汉 430060；3. 武汉市中西医结合医院皮肤科，湖北武汉 430022；4. 武汉科技大学附属天佑医院中西医结合科，湖北武汉 430064

发布日期:2022-12-19
通讯作者: 詹黎
作者简介:王胜强（1980— ），男，主治医师，硕士，研究方向：中西医结合治疗皮肤病。
基金资助:
国家中医药管理局基金资助项目（2013-22）；武汉市卫健委基金资助项目（WZ16B03）

Efficacy Observation and Mechanism Discussion of Mintuole Combined with Fire Acupuncture in Treating Chronic Eczema

WANG Shengqiang¹，PI Xianming²，LI Kai³，ZHAN Li^*4

1. Department of Dermatology/Integrated Traditional Chinese and Western Medicine，Central China Normal University Hospital，Wuhan 430079，Hubei，China；2. Department of Dermatology，Hubei Provincial Hospital of Traditional Chinese Medicine，Wuhan 430060，Hubei，China；3. Department of Dermatology，Wuhan Hospital of Traditional Chinese and Western Medicine，Wuhan 430022，Hubei，China；4. Department of Traditional Chinese and Western Medicine，Tianyou Hospital Affiliated to Wuhan University of Science and Technology，Wuhan 430064，Hubei，China

Published:2022-12-19
Contact: ZHAN Li

摘要/Abstract

摘要： 目的 观察中药复方制剂敏脱乐配合火针疗法治疗慢性湿疹的临床疗效，并进一步探讨可能的作用机制。方法 选取临床病例 286 例，随机双盲原则分为对照组和观察组。对照组给予西药常规抗过敏治疗，观察组给予中药方剂敏脱乐口服配合火针外治法。治疗 4 周之后评估疗效。进一步借助网络药理学和生物信息学理论，对两组患者治疗前后进行差异基因分析，选取 INF-γ、IL-4 及 EOS、IgE 作为疗效观察指标，探讨药物作用机制。结果 临床观察中观察组有效率 89. 7%，对照组有效率 77. 2%，观察组治疗效果优于对照组（P < 0. 05）。评估湿疹面积和严重程度指数（EASI）和皮肤病生活质量指数（DLQI）评分变化，观察组评分下降较对照组明显（P < 0. 05）。实验研究中，观察组较对照组治疗后 IL-4、EOS、IgE 降低明显，INF-γ 升高明显（P < 0. 05）。结论 中药方剂敏脱乐配合火针疗法治疗慢性湿疹疗效确切，且能明显调节机体免疫机制，在湿疹治疗中起到积极作用，值得在临床中推广运用。

关键词: 中药方剂, 火针, 慢性湿疹, 疗效观察, 作用机制

Abstract: Objective To observe the clinical efficacy of the traditional Chinese medicine compound Mintuole combined with fire acupuncture in the treatment of chronic eczema，and further explore the possible action mechanism. Methods A total of 286 clinical cases were selected and randomly divided into the control group and the observation group according to the double-blind principle. The control group was given conventional anti-allergic treatment， and the observation group was given Mintuole orally combined with fire needling external therapy. Efficacy was assessed after 4 weeks of treatment. Further，based on network pharmacology and bioinformatics' theory，the differential genes of the two groups of patients were analyzed before and after treatment. INF- γ，IL-4，EOS，and IgE were selected as the efficacy observation indexes to explore the mechanism of drug action. Results In the clinical observation，the effective rate of the observation group was 89. 7% and the effective rate of the control group was 77. 2%. The therapeutic effect of the observation group was better than that of the control group（P < 0. 05）. Eczema area and severity index（EASI）and dermatology life quality index（DLQI）scores were evaluated. The scores in the observation group decreased significantly compared with those in the control group（P < 0. 05）. In the experimental study，compared with the control group，IL-4，EOS，and IgE in the observation group were significantly decreased， and INF- γ was significantly increased after treatment（P < 0. 05）. Conclusion Mintuole combined with fire acupuncture therapy is effective in treating chronic eczema and can significantly regulate the body's immune mechanism.

Key words: traditional Chinese medicine prescription, fire acupuncture, chronic eczema, curative effect observation, action mechanism

中图分类号:

R275.958.23

王胜强，皮先明，李凯，詹黎，王胜强，皮先明，李凯，詹黎. 中药方剂敏脱乐配合火针治疗慢性湿疹疗效观察及作用机制探讨[J]. 江汉大学学报（自然科学版）, 2022, 50(6): 69-80.

WANG Shengqiang，PI Xianming，LI Kai，ZHAN Li. Efficacy Observation and Mechanism Discussion of Mintuole Combined with Fire Acupuncture in Treating Chronic Eczema[J]. Journal of Jianghan University (Natural Science Edition), 2022, 50(6): 69-80.

[1]	张林，陈翔，吴宇，于敏，蔡洪梅，柳彬彬，倪芊芊，刘绿洲，许辉，房浩，李金才. 脯氨酸在植物抗逆中的研究进展[J]. 江汉大学学报（自然科学版）, 2023, 51(1): 42-51.
[2]	杨光，施璐. 基于数据挖掘及体外实验探讨复方中药治疗肥胖的机制及药效[J]. 江汉大学学报（自然科学版）, 2023, 51(1): 52-63.
[3]	乔宇，袁发浒，卯玉嵘，王昕，胡骏，赵志刚. 基于网络药理学探讨桃红四物汤促进骨折愈合的主要活性成分及作用机制[J]. 江汉大学学报（自然科学版）, 2022, 50(4): 53-62.
[4]	杨光. 运用生物信息学及分子对接探讨熊果酸治疗宫颈癌的分子机制[J]. 江汉大学学报（自然科学版）, 2021, 49(6): 63-71.

中药方剂敏脱乐配合火针治疗慢性湿疹疗效观察及作用机制探讨

Efficacy Observation and Mechanism Discussion of Mintuole Combined with Fire Acupuncture in Treating Chronic Eczema

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 4

编辑推荐

Metrics

本文评价